Introduction
While GLP-1 receptor agonists like Wegovy, Ozempic, Zepbound and Mounjaro have proven effective for weight loss, they may not be suitable or accessible for everyone. This article explores non-GLP-1 alternatives, including other prescription drugs, over-the-counter options, and lifestyle changes.
Phentermine-Based Medications
Phentermine is one of the most well-known appetite suppressants and has been in use for several decades. It can be prescribed alone or in combination with topiramate (Qsymia).
- Mechanism of Action: Phentermine works by decreasing appetite and increasing energy expenditure.
- Potential Side Effects: Phentermine is a stimulant and can cause side effects like increased heart rate, dry mouth, and insomnia.
Lifestyle Modifications
Lifestyle changes, although not pharmaceutical, play a critical role in weight management. These include:
- Diet: Adopting a balanced, whole-food diet with controlled portion sizes.
- Exercise: Regular physical activity, including aerobic and strength training exercises.
- Behavioral Therapy: Incorporating behavior modification strategies to promote healthier eating patterns.
Other Prescription Medications
- Orlistat (Alli, Xenical): Works by preventing the absorption of fat in the intestines. However, it may cause gastrointestinal side effects like diarrhea and abdominal discomfort.
- Liraglutide (Saxenda): Another GLP-1 agonist but administered more frequently than Zepbound/Wegovy for weight loss purposes. It touts less weight loss benefit, but it may be covered by your pharmacy benefits.
WebMD – Weight Loss Medication Overview
Over-the-Counter Options
Certain OTC supplements claim to assist with weight loss. However, caution is advised due to variability in effectiveness and safety. Some examples include caffeine-based supplements, green tea extracts, and fiber-based products.
Conclusion
While GLP-1 drugs have proven effective, there are alternative prescription medications, lifestyle interventions, and OTC options that can be considered. Hopefully this info can jumpstart a conversation with your healthcare provider before starting any weight loss strategy to ensure it’s safe and effective for you.
