How Long Does Wegovy Stay in Your System?

Introduction
Wegovy (Semaglutide) is a medication used for weight loss, but understanding its pharmacokinetics—specifically how long it stays in your system—can be important for managing side effects, planning discontinuation, or switching medications.

Pharmacokinetics of Wegovy

  • Half-Life: The half-life of Wegovy is approximately 7 days.
  • Full Elimination: It typically takes about 5 half-lives for a drug to be cleared from the system, so Wegovy will generally be fully eliminated in about 5 weeks after the last dose.

Factors Influencing Elimination

  • Dosage and Duration of Use: Longer use or higher doses may prolong the presence of the drug in your system.
  • Renal Function: Impaired kidney function may slow down the elimination process.
ParameterDetails
Half-Life7 days
Full Clearance~5 weeks after last dose
Impact of Renal FunctionDelays elimination

Conclusion
Wegovy stays in your system for approximately 5 weeks after the last dose. Understanding this timeline can help in planning medication adjustments or addressing any side effects.

About Andrew

Hey! I’m Andrew Gilberto Vargas, a pharmacist and writer. I reflect on concepts that shape pharmacy benefits, drug access, leadership and meaning-making. Always curious, always learning.

Andrew Vargas, PharmD

About the Author

Andrew Vargas, PharmD is a Pharmacist practicing watchdoggery and founder of Pharmacist Write. He builds coverage intelligence tools and writes about what pharmacy benefits managers would prefer stayed invisible—turning policy into something patients, consultants, and purchasers can actually use.

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