Introduction
Switching weight loss medications, such as from Zepbound to Wegovy, can be a strategic decision influenced by factors like side effects, cost, and efficacy. Listening to your body and understanding what works for you is always best.

Comparative Mechanisms

• Zepbound (tirzepatide): A GLP-1/GIP agonist that increases satiety and decreases appetite, helping to control food intake. It’s now the superior weight-loss option
• Wegovy (semaglutide): A GLP-1 agonist that increases satiety and decreases appetite, helping to control food intake.

Dosage Conversion
Switching from Zepbound to Wegovy (I’d recommend switching the other way) requires proper dose adjustment. Here’s a rough dosage conversion table for reference, but please note, there is no clinically agreed upon dose conversion:

Note: Always consult with your healthcare provider before making any adjustments.

Transition Process

• Step 1: Stop Zepbound as directed by your provider. These are weekly drugs, so a 1-2 week washout period might be best to reduce the chances of side effects.
• Step 2: Begin Wegovy at the advised dose and monitor for any side effects (it’s always the side effects..)
• Step 3: Follow-up with your provider to ensure the dose is appropriate. 1.7mg and 2.4mg are the recommended maintenance doses

Insurance and Cost Considerations
The cost and coverage for Wegovy can differ from Zepbound. It’s smart to verify with your insurance provider if coverage is an option or explore savings programs for potential cost relief. Most employers, unfortunately, aren’t covering these drugs specifically for weight loss, making the out-of-pocket expense unreasonable for most Americans.

Conclusion
Transitioning between weight loss medications should be carefully managed with professional support. You definitely should not be taking both together. Each patient’s journey is unique, and finding the right medication may require some trial and adjustment.