Introduction:

Wegovy and Victoza are both GLP-1 receptor agonists, which means they help lower blood sugar and can also help with weight loss. Victoza is used to treat Type 2 diabetes. Wegovy is used to treat weight loss management and reduce cardiovascular risk. Although they are similar, there are some key differences.

Mechanism of Action:

•             Similarities: Both Wegovy and Victoza help the body release insulin after you eat. They also slow down how quickly food leaves your stomach, which can help you feel full.

•             Differences: One big difference is how long they last. Victoza is taken every day, while Wegovy is taken once a week. Wegovy also binds to the GLP-1 receptor a little more strongly than Victoza, which makes the effects, both intended and side effects, more pronounced. Victoza is also now generic.

Efficacy:

•             A1c reduction: Both Wegovy and Victoza help lower A1c levels (a measure of blood sugar control). Studies show that Wegovy lowers A1c more than Victoza. However, Wegovy was studied for weight loss management, not diabetes management.

•             Weight loss: Both drugs can help with weight loss, but people on Wegovy will lose more weight than those on Victoza.

Side Effects:

•             Wegovy: Common side effects include nausea, diarrhea, and stomach pain.

•             Victoza: Victoza has similar side effects, like nausea and vomiting.

•             Long-term safety: Both drugs are generally safe for long-term use, but it’s important to talk to your doctor if you have a history of certain types of cancer or severe stomach issues.

Cost and Insurance Coverage:

•             Price comparison: Wegovy and Victoza are both expensive, with Wegovy being significantly more. However, some insurance plans will cover part of the cost.

•             Patient assistance programs: Both drugs offer patient assistance programs to help those who can’t afford them.

Wegovy and Victoza patient assistance program

Conclusion:

Wegovy and Victoza are both great cardiometabolic drugs. Wegovy is more effective and will help with weight loss management, but Victoza is a solid choice, too, especially if cost is a primary concern. Talk to your doctor to figure out which one is right for you.