Lantus and Toujeo are basal insulins, meaning they provide a steady release of insulin over an extended period to manage blood sugar levels. Both are manufactured by Sanofi and are part of the same insulin family, but they differ in concentration, duration of action, and dosing requirements.
How Do Lantus and Toujeo Work?
Lantus: Mechanism of Action
Lantus (insulin glargine U-100) releases insulin gradually over 24 hours. It helps maintain blood sugar stability between meals and overnight by mimicking the natural, low-level insulin secretion of the pancreas.
Toujeo: Mechanism of Action
Toujeo (insulin glargine U-300) is a more concentrated form of insulin glargine. Its higher concentration means you can inject a smaller volume of insulin, but it provides the same gradual, 24-hour glucose control as Lantus. For some patients, Toujeo’s longer duration of action can be an advantage.
How Effective Are Lantus and Toujeo?
Blood Sugar Control
Both Lantus and Toujeo are highly effective in managing blood sugar levels over a 24-hour period. Clinical studies show that their efficacy in lowering HbA1c levels is comparable, making them reliable options for basal insulin therapy.
Duration of Action
- Lantus: Provides coverage for up to 24 hours.
- Toujeo: Lasts slightly longer than 24 hours in many cases, which can be beneficial for patients who experience blood sugar fluctuations at the end of a dosing cycle.
Dosing Considerations
Because Toujeo is more concentrated, patients may require smaller injection volumes compared to Lantus. This can enhance convenience and comfort, especially for those requiring higher insulin doses.
Side Effects of Lantus and Toujeo
Common Side Effects
- Lantus: May cause hypoglycemia (low blood sugar), weight gain, and mild injection site reactions like redness or swelling.
- Toujeo: Shares similar side effects, including hypoglycemia and localized injection site irritation.
Rare or Serious Side Effects
In rare cases, both insulins can cause allergic reactions, such as rash or difficulty breathing. Patients should contact their healthcare provider immediately if severe reactions occur.
Cost and Accessibility of Lantus vs. Toujeo
Price Comparison
Both Lantus and Toujeo are premium insulins, and their costs can be a concern for many patients. Without insurance, prices can range from $300–$400 per vial or pen pack. However, the actual out-of-pocket cost depends on insurance coverage, units per day and pharmacy discounts.
Patient Assistance Programs
Sanofi offers patient assistance programs for both Lantus and Toujeo. These programs can significantly reduce costs for eligible patients. Additionally, some savings cards or copay programs may be available for those who qualify. Typically these programs are income-based or can be linked to coverage denials due to formulary preferred alternatives
Generic and Biosimilar Options
In recent years, biosimilar insulins like Semglee (insulin glargine-yfgn) have become available as cost-effective alternatives to Lantus. These options can provide similar benefits at a lower price point. Regular insulins can also be more favorably priced.
Which Insulin Is Right for You?
Choosing between Lantus and Toujeo depends on your individual needs, lifestyle, and medical history. Here are some factors to consider:
- Injection Volume: If you require a higher insulin dose, Toujeo’s smaller injection volume might be more comfortable.
- Duration Needs: Toujeo’s slightly longer action may benefit patients who experience blood sugar fluctuations at the end of a 24-hour dosing cycle.
- Cost: Insurance coverage and assistance programs can influence affordability.
Always consult your healthcare provider to determine which insulin aligns best with your treatment goals.
Frequently Asked Questions (FAQs)
1. Is Toujeo stronger than Lantus?
Toujeo is not “stronger” than Lantus but is more concentrated. This allows for smaller injection volumes while delivering the same blood sugar-lowering effects.
2. Can I switch from Lantus to Toujeo?
Yes, many patients switch between these insulins under medical supervision. Dose adjustments may be necessary due to differences in concentration and absorption rates.
3. Are Lantus and Toujeo safe for Type 1 diabetes?
Yes, both insulins are approved for use in patients with Type 1 and Type 2 diabetes. However, they must be used as part of a comprehensive diabetes management plan, including mealtime insulin and lifestyle adjustments.
4. What is the difference in onset time for Lantus and Toujeo?
Both insulins have a gradual onset of action, typically starting to work within 1-2 hours after injection.
Conclusion
Both Lantus and Toujeo are effective options for long-acting blood sugar control in people with diabetes. If you prefer a smaller injection volume or need a slightly longer duration of action, Toujeo might be a better fit. Always consult your provider to discuss your needs and determine the best insulin therapy for your diabetes management plan.
